ICGC Goals, Structure, Policies and Guidelines (February 2010)

ICGC Goal: To obtain a comprehensive description of genomic, transcriptomic and epigenomic changes in 50 different tumor types and/or subtypes which are of clinical and societal importance across the globe.

Coordination

An International Scientific Steering Committee (ISSC) will be constituted with the principal investigators of cancer genome projects in the ICGC, the Data Coordination Center, expert pathologists, oncologists and ethicists, and representatives of funding agencies. This group will interact frequently, through phone conferences, e-mail and regular meetings, to:

  • act as a science coordinating body;
  • evaluate progress;
  • address arising issues of a scientific nature, including those related to samples, consent, ethics, quality
    standards, evolving technologies;
  • exchange protocols, standard operating procedures;
  • establish temporary or permanent subcommittees that would be assigned focused tasks;
  • establish QC standards.

A Data Coordination Center (DCC) will manage data flow from projects and centers to the central ICGC database, public repositories, quality assessment, curation and data releases (see details in section E.9 Data Management). The DCC will provide regular progress reports to the EXEC and ISSC.

Quality Assessment Centers Quality assessment of the samples used in cancer genome projects is critical to the success of the project. To that end, the Consortium may consider establishing quality assessment centers. The issue of ‘round robin’ style versus 3rd party quality assessment will require further discussion, as well as mechanisms for funding such activities.

Coordination Support Staffing will be committed to help manage the operations of the ICGC committees.


An International Scientific Steering Committee (ISSC) will be constituted with the principal investigators of cancer genome projects in the ICGC, the Data Coordination Center, expert pathologists, oncologists and ethicists, and representatives of funding agencies. This group will interact frequently, through phone conferences, e-mail and regular meetings, to:

  • act as a science coordinating body; * evaluate progress; * address arising issues of a scientific nature, including those related to samples, consent, ethics, quality
    standards, evolving technologies;
  • exchange protocols, standard operating procedures; * establish temporary or permanent subcommittees that would be assigned focused tasks; * establish QC standards.

A Data Coordination Center (DCC) will manage data flow from projects and centers to the central ICGC database, public repositories, quality assessment, curation and data releases (see details in the Data Management section found later in this document). The DCC will provide regular progress reports to the EXEC and ISSC. Quality Assessment Centers Quality assessment of the samples used in cancer genome projects is critical to the success of the project. To that end, the Consortium may consider establishing quality assessment centers. The issue of ‘round robin’ style versus 3rd party quality assessment will require further discussion, as well as mechanisms for funding such activities. Coordination Support Staffing will be committed to help manage the operations of the ICGC committees.

Last Updated on: 7 February 2010